Dr. Alpdoğan KANTARCI holds a D.D.S. and a Ph.D. degree. He is also a certified specialist of Periodontology (C.A.G.S.) and a Diplomate of the American Board of Periodontology. He is an Associate Member of the Staff at the Forsyth Institute in Cambridge, MA, USA, and serves as an Associate Professor at Boston University’s Henry Goldman School of Dental Medicine and at Harvard University School of Dental Medicine. He has started his career as a dentist after graduating from Istanbul University in 1991. He completed his clinical and PhD studies at Istanbul University at the Department of Periodontology joining the faculty. He moved to the USA in 1999 as a postdoctoral fellow at Boston University. Upon completing his postdoctoral studies in 2002, he has started clinical periodontology specialization training at Boston University. After graduating, he was appointed as an Assistant Professor in 2004 at the Goldman School of Dental Medicine. He was promoted to the Associate Professorship in 2009. In 2010, he joined the Forsyth Institute and Harvard University maintaining his faculty position at Boston University. He also serves as the clinical practice director at the Forsyth Institute. During his academic career, Dr. Kantarci has been actively involved in training, education and patient care. He has mentored more than 50 PhD, doctorate, and Master’s theses; directed and taught in several graduate and postgraduate clinical and didactic dentistry courses. He serves in the editorial board and as a reviewer of more than 20 dental and medical scientific journals. His research interests include Molecular Mechanisms and Resolution Pathways of Oral Inflammation in Periodontitis, Experimental Models; Signal Transduction in Neutrophils and Monocytes in Inflammatory Diseases, Clinical Applications of High-Throughput Analysis in Dental Research (e.g. xMAP Multiplexing), and Biology of Surgery-Assisted Tooth Movement. He holds several patents. He has published more than 130 articles in peer-reviewed scientific journals, wrote book chapters, and has presented more than 400 oral talks and posters in dental and medical congresses.
Aging is a complex biological process involving progressive physiological changes in an organism that lead to decline in biological functions and the organism’s ability to adapt to metabolic stress with time. The process of aging affects both the innate and adaptive immune responses and might be a contributing factor in the inflammatory diseases like chronic inflammatory periodontitis. Study of aging is an emerging discipline, and while there is general understanding of the aging process, there is limited information about fundamental biological processes taking place in the gingival tissue as we age. Novel molecular methods offer means to identify pathways associated with healthy aging, as well as allow us to evaluate the impact of aging on progression of oral diseases. This lecture will review the recent advances in this field of research including molecular pathways associated with gingival aging, the effect of aging on histological changes, level of inflammatory biomarkers, apoptosis and progression of periodontal and peri-implant diseases