Chair of department Oral and Maxillofacial Tissue Engineering. International Society of Regenerative Medicine and BioMedical Innovation.
Lecturer department of Clinical Anatomy, Tbilisi State Medical University.
Dentist and Oral Surgeon of St. Antipa Dental Clinic, Tbilisi, Georgia
For many centuries, regenerating lost teeth has been a dream for dentists. Recently, tissue engineering has been providing such an opportunity. The main basis of bioengineering incorporates the use of cells, scaffolds and signaling molecules. Currently, two approaches are considered for tooth bioengineering: a) Scaffold based approach which involves using scaffolds on which cells can be planted either in vitro or by cell homing. Cell homing involves in situ induction of endogenous stem cells from adjacent host sites to mobilize and inhabit the native host matrix or implanted scaffold matrix; b) Scaffold free approach aims at directly inducing developmental processes of embryonic tooth formation guided by appropriate signals to produce tooth structures that mimic natural teeth in morphology and size. The presented research considers the possibility of growing a new tooth in vivo from the decellularized swine tooth scaffold and dental pulp stem cells.